Protein destruction: Adapting roles for Cks proteins
نویسنده
چکیده
Cks1, a subunit of cyclin-dependent kinases, has now been identified as an essential cofactor in the ubiquitination of the Cdk inhibitor p27 by the SCF(Skp2) ubiquitin ligase. This activity, which can be independent of Cdk binding, links Cks to positive growth control pathways regulating the G1/S transition and to cancer.
منابع مشابه
Cell cycle: Reaching for a role for the Cks proteins
The Cks proteins are essential components of the cyclin-dependent protein kinases that regulate mitosis in all eukaryotes, but their precise function remains obscure. The crystal structures of several Cks proteins offer insights into their roles during the cell cycle.
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عنوان ژورنال:
- Current Biology
دوره 11 شماره
صفحات -
تاریخ انتشار 2001